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The Science

Optical Tweezers Microrheology

Harness the power of light to measure the mechanical properties of complex fluids with unprecedented precision and minimal sample disturbance.

The Foundation

What are Optical Tweezers?

Optical tweezers use a tightly focused laser beam to create a three-dimensional optical trap. When light passes through a microscopic bead, the gradient in light intensity creates forces that pull the bead toward the focal point.

This Nobel Prize-winning technology (Arthur Ashkin, 2018) allows us to hold and manipulate microscopic objects with piconewton precision—all without any physical contact with the sample.

Key Advantage

Non-invasive measurement that doesn't disturb delicate sample structures like gels, emulsions, or biological materials.

Optical Trap1064nm Laser

The Method

How Microrheology Works

Understanding the principles behind our precision measurements.

Optical Trapping

A highly focused laser beam creates a gradient force that can trap and hold microscopic particles in three dimensions. This allows precise positioning and manipulation of probe beads within your sample.

Brownian Motion Analysis

By analyzing the thermal fluctuations of trapped beads, we extract information about the local viscosity and viscoelastic properties of the surrounding medium with exceptional sensitivity.

Active Microrheology

Beyond passive observation, we can actively oscillate trapped beads at controlled frequencies to directly measure the frequency-dependent viscoelastic response (G' and G").

Advanced Analysis

Sophisticated algorithms process position data in real-time, applying the generalized Stokes-Einstein relation and other models to compute rheological parameters.

See It In Action

Explore our interactive microrheology simulation to understand how optical tweezers trap particles and measure their Brownian motion in real-time.

Measurement Outputs

Viscosity (η)
Dynamic viscosity in Pa·s
G' (Storage Modulus)
Elastic component in Pa
G" (Loss Modulus)
Viscous component in Pa
Frequency Response
G'(ω), G"(ω) across frequency range

Results You Can Trust

Comprehensive Rheological Data

Our optical tweezers platform provides complete viscoelastic characterization of your samples. From simple Newtonian fluids to complex structured materials, get the data you need.

  • Real-time viscosity measurements
  • Frequency-dependent viscoelastic moduli
  • Automated data analysis and reporting
  • Export to common data formats

Advantages Over Traditional Rheometry

See why optical tweezers microrheology is the next generation of rheological measurement.

Microscale Probe

mm-scale geometries
Micron-sized probe particles

Sample Volume

mL of sample required
Microliters sufficient

Contact Method

Mechanical contact
Non-contact optical

Local Properties

Bulk average only
Spatially resolved

Delicate Samples

May damage structures
Gentle, non-invasive

Automation

Manual operation
Fully automated
Complementary Technology

Confocal Raman Spectroscopy

Where optical tweezers reveal the mechanical properties of a sample, Raman spectroscopy reveals its molecular structure. The Finder 930 analyzes inelastically scattered light to produce a unique “molecular fingerprint” — enabling non-destructive identification, stress and crystal-orientation analysis, and sub-micron chemical mapping.

Explore the Finder 930 Raman platform
Molecular fingerprint identification
Sub-micron spatial resolution
Stress & strain mapping
Crystal orientation & quality

Want to Learn More?

Our team is ready to discuss how optical tweezers microrheology can advance your research or quality control processes.